BubR1 is frequently repressed in acute myeloid leukemia and its re-expression sensitizes cells to antimitotic therapy

Spindle poison-based therapy is of only bostik universal primer pro limited benefit in acute myeloid leukemia while lymphoblastic leukemia/lymphoma responds well.In this study, we demonstrated that the spindle assembly checkpoint protein BubR1 was down-regulated in the vast majority of cases of acute myeloid leukemia whereas its expression was high

read more

Multiphase modelling of glioma pseudopalisading under acidosis

We propose a multiphase modeling approach to describe glioma pseudopalisade patterning under the influence of acidosis.The hydrangea red sensation phases considered at the model onset are glioma, normal tissue, necrotic matter, and interstitial fluid in a void-free volume with acidity represented by proton concentration.We start from mass and momen

read more

Optic neuropathy associated with GVHD after bone marrow allogeneic hematopoietic stem cell transplantation for B-Acute lymphoblastic leukemia: case report

Abstract Background Graft-versus-host disease (GVHD) is the most common complication after bone marrow allogeneic hematopoietic stem cell transplantation (allo-HSCT).The incidence of posterior segment complications was significantly lower than that of ocular surface lesions.Up to now, there has been no report about optic neuropathy associated with

read more


Prostrate or upright growth habit in tomato cultivars: contributory roles of stem diameters and fruit weight under fertilizer application

For increased production of fresh market tomato fruits, identification of cultivars that combine upright growth habit (UGH) and increased fruit weight under increased fertilizer rates is essential.Six tomato cultivars comprising five improved types namely Tropimech, Buffalo, Roma VF, Roma Savana, UC 82 and a local cultivar Kerewa were evaluated to

read more